An association between the natural course of shoulder joint destruction in rheumatoid arthritis and HLA-DRB1*0405 in Japanese patients.

Abstract

To assess the association between HLA-DRB1 alleles and shoulder destruction due to rheumatoid arthritis (RA) in Japanese, we typed for HLA-DRB1 alleles in 100 Japanese RA patients who could be classified into 5 groups: non-progressive (N) with normal radiographs; erosive (E) showing marginal erosion but no collapse; collapse (C) showing subchondral cysts followed by collapse; arthrosis-like (A) showing osteoarthrotic features; and the mutilating (M) showing mutilating bone destruction. The HLA-DRB1*0405 antigen frequency in N, E, C, A, and M types was 55%, 61%, 33%, 71%, 100%, respectively. That in the M type (100%) was significantly higher than that in the others (the N, E, C, and A types; 57%). These findings suggest that the most severe shoulder joint destruction pattern in RA, the M type, is associated with HLA-DRB1*0405.

• Authors: S Wakitani, K Imoto, N Murata, H Oonishi, T Ochi, M Yoneda
• Journal: Scandinavian journal of rheumatology (Scand J Rheumatol) Vol. 27 Issue 2 Pg. 146-8 ( 1998) ISSN: 0300-9742 [Print] England
• PMID: 9572642 (Publication Type: Journal Article)

Chemical References

• HLA-DR Antigens
• HLA-DRB1 Chains

Topics

• Adult
• Aged
• Aged, 80 and over
• Arthritis, Rheumatoid (ethnology, genetics, pathology)
• Disease Progression
• Female
• Gene Frequency
• Genotype
• HLA-DR Antigens (genetics)
• HLA-DRB1 Chains
• Humans
• Japan (ethnology)
• Male
• Middle Aged
• Radiography
• Shoulder Joint (diagnostic imaging, pathology)