Inhibitory effect of F-1322 on allergic eosinophil infiltration in airways.

Abstract

The effects of F-1322 (N-[2-[4-(benzhydryloxy)piperidino]ethyl]-3-hydroxy-5-(3-pyridy lmethoxy)-2-naphthamide) on antigen-induced eosinophil infiltration and interleukin-5 production in the airways and on in vitro eosinophil migration were investigated. F-1322 (10-30 mg/kg, p.o.) inhibited antigen-induced eosinophil infiltration and interleukin-5 production in the airways of sensitized mice in a dose-dependent manner. Furthermore, F-1322 (0.1-10 microM) prevented the in vitro migration of eosinophils from guinea-pigs and humans induced by recombinant human interleukin-5, platelet-activating factor, and leukotriene B4 in a concentration-dependent manner. These results indicate that F-1322 has an inhibitory effect on allergic eosinophil infiltration of the airways by preventing both eosinophil migration and interleukin-5 production. These pharmacological profiles suggest that F-1322 will be a useful therapeutic for allergic diseases, especially asthma.

• Authors: A Mochizuki, B Lee, M Shibata, M Kasai, T Tanaka, I Iwamoto
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 343 Issue 2-3 Pg. 233-7 (Feb 19 1998) ISSN: 0014-2999 [Print] Netherlands
• PMID: 9570472 (Publication Type: Journal Article)

Chemical References

• Anti-Asthmatic Agents
• F 1322
• Interleukin-5
• Naphthalenes

Topics

• Animals
• Anti-Asthmatic Agents (pharmacology)
• Bronchoalveolar Lavage Fluid
• Cell Movement (drug effects)
• Eosinophils (cytology, drug effects)
• Female
• Guinea Pigs
• Humans
• Hypersensitivity (pathology)
• Interleukin-5 (biosynthesis)
• Mice
• Mice, Inbred BALB C
• Naphthalenes (pharmacology)
• Trachea (drug effects, pathology)