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Review of the estrogenic and antiestrogenic activity of polycyclic aromatic hydrocarbons: relationship to carcinogenicity.

Abstract
Human exposure to nonsteroidal estrogens in the environment has recently been proposed as a risk factor for endocrine disruption and the development of cancers of the breast and reproductive tract. Certain polycyclic aromatic hydrocarbons (PAHs), which closely resemble steroid hormones, are ubiquitous environmental contaminants whose carcinogenicity has been extensively studied. This review examines the available evidence regarding the actions of PAHs on estrogen receptor activity, estrogen metabolism and the hypothalamo-pituitary axis. In most studies, PAHs exhibited either weakly estrogenic or antiestrogenic responses. The possibility is raised that the endocrine toxicology of certain PAHs reflects both genotoxic and non-genotoxic components which may be interrelated, particularly with regard to carcinogenesis.
AuthorsJ Santodonato
JournalChemosphere (Chemosphere) Vol. 34 Issue 4 Pg. 835-48 (Feb 1997) ISSN: 0045-6535 [Print] England
PMID9569946 (Publication Type: Journal Article, Review)
Chemical References
  • Carcinogens
  • Estrogen Antagonists
  • Polycyclic Aromatic Hydrocarbons
  • Receptors, Estrogen
Topics
  • Animals
  • Binding, Competitive
  • Carcinogens (adverse effects, toxicity)
  • Environmental Exposure
  • Estrogen Antagonists (adverse effects, toxicity)
  • Humans
  • Neoplasms, Experimental (chemically induced, etiology)
  • Pituitary-Adrenal System (drug effects, metabolism)
  • Polycyclic Aromatic Hydrocarbons (adverse effects, toxicity)
  • Receptors, Estrogen (antagonists & inhibitors, drug effects)
  • Risk Factors
  • Structure-Activity Relationship

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