Further characterization of forebrain serotonin receptors mediating tachycardia in conscious rats.

Abstract	It has been shown recently that activation of forebrain serotonin1A (5-HT1A) receptors, likely within the preoptic area, elicits a slight increase in blood pressure and a substantial tachycardia. The present studies were designed to characterize: (1) the requirement of the 5-HT1A receptor agonist R(+)-8-hydroxy-2-(di-n-propylamino) tetralin [R(+)8-OH-DPAT]-induced tachycardia on the integrity of serotonergic innervation of the preoptic area, (2) the ability of the 5-HT1A receptor partial agonist buspirone to elicit cardiovascular responses when microinjected into the preoptic area, (3) the role of 5-HT2 and 5-HT3 receptors in the preoptic area in cardiovascular regulation, and (4) the site specificity of the tachycardia produced by R(+)8-OH-DPAT. The data suggest that activation of 5-HT1A receptors, but not 5-HT2 or 5-HT3 receptors, within or very near the preoptic area increases blood pressure and heart rate in conscious rats. Furthermore, the full response is dependent on afferent serotonergic innervation, suggesting a presynaptic modulatory role for 5-HT in the preoptic area.
Authors	A Szabó, B L Butz, R H Alper
Journal	Brain research bulletin (Brain Res Bull) Vol. 45 Issue 6 Pg. 583-8 (Apr 1998) ISSN: 0361-9230 [Print] United States
PMID	9566502 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Receptor, Serotonin, 5-HT2A Receptors, Serotonin Receptors, Serotonin, 5-HT1 Receptors, Serotonin, 5-HT3 5,7-Dihydroxytryptamine Serotonin 8-Hydroxy-2-(di-n-propylamino)tetralin Buspirone Dopamine Norepinephrine
Topics	5,7-Dihydroxytryptamine (pharmacology) 8-Hydroxy-2-(di-n-propylamino)tetralin (pharmacology) Animals Blood Pressure (drug effects) Buspirone (pharmacology) Dopamine (metabolism) Heart Rate (drug effects) Male Norepinephrine (pharmacology) Preoptic Area (drug effects, physiology, physiopathology) Prosencephalon (drug effects, physiology, physiopathology) Rats Rats, Sprague-Dawley Receptor, Serotonin, 5-HT2A Receptors, Serotonin (drug effects, physiology) Receptors, Serotonin, 5-HT1 Receptors, Serotonin, 5-HT3 Serotonin (metabolism, pharmacology) Synapses (physiology) Tachycardia (physiopathology)

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