Abstract |
The efficacy of hyperimmune bovine colostrum received from cows immunized with simian rotavirus SA11 in the treatment of rotavirus gastroenteritis was compared in a randomized double-blind trial to colostrum and ordinary milk preparations. One hundred and thirty-five children aged 6-30 months with rotaviral gastroenteritis received either hyperimmune bovine colostrum (n=42), ordinary colostrum (n=42) or milk (n=41) as a 100 ml solution four times/d for 4 d. Even though the differences were in favour of hyperimmune bovine colostrum in all the variables evaluated [greater weight gain (403 vs 343 g), shorter duration of diarrhoea (3.1 vs 3.6 d), fewer stools during 6 d (11.5 vs 13.6) and fewer stools during the first 3 d (9.3 vs 11.3)], all the differences were statistically insignificant. Differences of this size are clinically unimportant in well-nourished immunocompetent children, but we suggest that the hyperimmune bovine colostrum tested in our trial had some effects in the treatment of acute rotaviral gastroenteritis and should be evaluated further.
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Authors | S Ylitalo, M Uhari, S Rasi, J Pudas, J Leppäluoto |
Journal | Acta paediatrica (Oslo, Norway : 1992)
(Acta Paediatr)
Vol. 87
Issue 3
Pg. 264-7
(Mar 1998)
ISSN: 0803-5253 [Print] Norway |
PMID | 9560031
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antibodies, Viral
- Antigens, Viral
- SA-11 antigen, Rotavirus
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Topics |
- Animals
- Antibodies, Viral
(administration & dosage, immunology)
- Antigens, Viral
(immunology)
- Cattle
- Child, Preschool
- Colostrum
(immunology)
- Confidence Intervals
- Double-Blind Method
- Female
- Gastroenteritis
(immunology, therapy, virology)
- Humans
- Immunization
(methods)
- Infant
- Male
- Milk
(immunology)
- Reference Values
- Rotavirus Infections
(immunology, therapy)
- Treatment Outcome
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