HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Evolution of brain tuberculomas under standard antituberculous treatment.

Abstract
The treatment of brain tuberculomas is primarily medical. Surgery, excision or biopsy, is generally performed when the diagnosis is in doubt or there is no response to medical therapy. The aim of this study was to determine the radiological evolution of intracranial tuberculomas under standard anti-tuberculous drug therapy and to establish guidelines for better management of these patients. Eighteen patients were studied retrospectively. None of them had surgical intervention and all were treated by standard antituberculous drugs and had serial computed tomography (CT) scans until disappearance or stabilization of brain lesions. The regression of lesions' size and number was slow in the first month (mean -7.3%) then became rapid after this (-15% to -20% per month). A paradoxical increase in size was noted in three patients in the first month. All three had associated meningitis. All tuberculomas disappeared on CT scan after 12 months of therapy. Most of the edema images disappeared by 6 months. This study would suggest that a long treatment regimen of 15-18 months may not be necessary in most intracranial tuberculomas occurring in non-immunocompromised patients. It also demonstrates that medical trial in well tolerated suspected cases should last for at least 2 months before considering other etiologies or surgical exploration.
AuthorsA Awada, A K Daif, M Pirani, M Y Khan, Z Memish, S Al Rajeh
JournalJournal of the neurological sciences (J Neurol Sci) Vol. 156 Issue 1 Pg. 47-52 ( 1998) ISSN: 0022-510X [Print] NETHERLANDS
PMID9559986 (Publication Type: Journal Article)
Chemical References
  • Antitubercular Agents
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antitubercular Agents (adverse effects)
  • Brain Diseases (etiology, radiography)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Tuberculoma (etiology, radiography)
  • Tuberculosis (complications, drug therapy, radiography)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: