Abstract | PURPOSE: MATERIALS AND METHODS: We retrospectively reviewed the records of 180 patients with genitourinary small cell carcinoma in which patient and tumor characteristics, therapy, followup duration and survival status had been documented. Patient age, sex, primary site, histological features, tumor size, stage, locoregional therapy, systemic chemotherapy and hormonal manipulations were analyzed for association with survival. RESULTS: There were 106 cases of bladder, 60 prostatic, 8 renal and 6 ureteral small cell carcinoma. Median survival was 10.5 months overall, and 7 and 13 months for prostatic and bladder small cell carcinoma, respectively (p <0.0001 log rank analysis). In all cases metastatic disease at presentation (p <0.008, risk ratio 1.9) predicted poor survival on multivariate analysis. Radical surgery (p <0.0001, risk ratio 0.34) and cisplatin chemotherapy (p <0.0001, risk ratio 0.20) were the only factors that predicted improved survival on multivariate analysis. For prostatic small cell carcinoma primary surgical therapy (p <0.012, risk ratio 0.46) was the only parameter that predicted survival on univariate analysis. For bladder small cell carcinoma only cisplatin chemotherapy (p <0.0001, risk ratio 0.15) predicted survival on multivariate analysis. CONCLUSIONS:
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Authors | J R Mackey, H J Au, J Hugh, P Venner |
Journal | The Journal of urology
(J Urol)
Vol. 159
Issue 5
Pg. 1624-9
(May 1998)
ISSN: 0022-5347 [Print] United States |
PMID | 9554367
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Small Cell
(mortality, surgery, therapy)
- Chemotherapy, Adjuvant
- Female
- Humans
- Kidney Neoplasms
(mortality, therapy)
- Male
- Middle Aged
- Prognosis
- Prostatic Neoplasms
(mortality, surgery, therapy)
- Radiotherapy, Adjuvant
- Retrospective Studies
- Survival Analysis
- Ureteral Neoplasms
(mortality, therapy)
- Urinary Bladder Neoplasms
(mortality, surgery, therapy)
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