Histology of the endometrium in long-term use of a sequential oral contraceptive.

Abstract

Non-atypical adenomatous hyperplasia was found in 13.5% of 111 biopsies obtained from long-term, predominantly black, users of Oracon. An association between length of time of use (95 cycles for those with adenomatous hyperplasia versus 73 for those without) and the development of adenomatous hyperplasia was noted, but there was no association with hypertension or obesity. Cystic glandular dilatation was seen in 63% but was not thought to represent hyperplasia. No more advanced lesions were seen.

• Authors: A Kreutner Jr, D Johnson, H O Williamson
• Journal: Fertility and sterility (Fertil Steril) Vol. 27 Issue 8 Pg. 905-10 (Aug 1976) ISSN: 0015-0282 [Print] United States
• PMID: 955133 (Publication Type: Journal Article)

Chemical References

• Contraceptives, Oral
• Contraceptives, Oral, Sequential

Topics

• Contraceptives, Oral
• Contraceptives, Oral, Sequential (adverse effects)
• Endometrium (anatomy & histology, drug effects, pathology)
• Female
• Humans
• Hyperplasia (pathology)
• Uterine Neoplasms (chemically induced)