Therapeutic effects of an injectable new quinolone, pazufloxacin, against polymicrobial infections in the uterine endometritis model.

Abstract	Polymicrobial infections with aerobes and anaerobes are common in female genital tract infections. We evaluated the efficacy of an injectable new quinolon, pazufloxacin, using a uterine endometritis model. Rats were infected with a mixed inoculation of Escherichia coli plus Bacteriodes fragilis (MIC of pazufloxacin and ceftazidime: E. coli: 0.05 and 1.56 micrograms/ml, respectively, B. fragilis: 3.13 and 3.13 micrograms/ml, respectively). After inoculating 10(7) cfu/rat of each organism, pazufloxacin or ceftazidime (10 or 20 mg/kg, respectively, i.v., b.i.d., 3 days) was administered and compared with the nontreated group. The viable cell counts of the uterine corpus and uterine cervix in pazufloxacin-treated and ceftazidime-treated groups were decreased, compared with the nontreated group. The viable cell counts of the adnexa in the pazufloxacin-treated group were significantly decreased, compared with the ceftazidimetreated group. These results suggest that pazufloxacin would be useful for the treatment of polymicrobial infections, especially adnexitis.
Authors	H Mikamo, K Kawazoe, Y Sato, T Tamaya
Journal	Chemotherapy (Chemotherapy) 1998 Mar-Apr Vol. 44 Issue 2 Pg. 99-102 ISSN: 0009-3157 [Print] Switzerland
PMID	9551239 (Publication Type: Comparative Study, Journal Article)
Chemical References	Anti-Infective Agents Cephalosporins Fluoroquinolones Oxazines pazufloxacin Ceftazidime
Topics	Animals Anti-Infective Agents (administration & dosage, therapeutic use) Bacteroides Infections Bacteroides fragilis (drug effects) Ceftazidime (administration & dosage, therapeutic use) Cephalosporins (administration & dosage, therapeutic use) Colony Count, Microbial Disease Models, Animal Dose-Response Relationship, Drug Endometritis (drug therapy, microbiology) Escherichia coli Infections Female Fluoroquinolones Genital Diseases, Female (drug therapy, microbiology) Injections, Intravenous Microbial Sensitivity Tests Oxazines (administration & dosage, therapeutic use) Rats Rats, Sprague-Dawley Species Specificity

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