| Abstract | A new hypothesis of the pathogenesis of psoriasis holds that psoriasis is an epidermal hyperproliferative disorder resulting from abnormal interaction between T cells and basal layer stem cell keratinocytes. New therapies aimed at reducing T cell activity are most successful, as exemplified by the efficacy of systemic cyclosporine in severe cases of psoriasis. New developments in immunogenetics and immunodermatology are anticipated and it is expected that they will fully explain the chain of pathological events. |
| Authors | J D Bos, M A de Rie
(Affiliation: Afd. Huidziekten, Academisch Medisch Centrum, Amsterdam.)
|
| Journal | Nederlands tijdschrift voor geneeskunde
(Ned Tijdschr Geneeskd)
Vol. 141
Issue 48
Pg. 2334-8
(Nov 29 1997)
ISSN: 0028-2162 NETHERLANDS |
| Vernacular Title | Immunologie in de medische praktijk. VII. Psoriasis. |
| PMID | 9550823
(Publication Type: English Abstract, Journal Article)
|
| Chemical References |
- Antibodies, Monoclonal
- Cyclosporins
- Immunosuppressive Agents
- Immunotoxins
|
| Topics |
- Antibodies, Monoclonal
(therapeutic use)
- Cyclosporins
(therapeutic use)
- Humans
- Immunogenetics
- Immunosuppressive Agents
(therapeutic use)
- Immunotherapy
(methods)
- Immunotoxins
(therapeutic use)
- Keratinocytes
(immunology)
- Psoriasis
(immunology, pathology, therapy)
- Stem Cells
(immunology)
- T-Lymphocytes
(immunology)
|
