HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Therapeutic properties.of haemodialysis and blood exchange transfusion in organophosphate poisoning.

Abstract
Human blood was contaminated with nitrostigmine, dimethoate and demeton-S-methyl sulfoxide. It was then dialysed, concentrations of organophosphates were determined and dialysance values calculated. The influence of blood exchange transfusion on poison elimination as well as on the cholinesterase activity of blood, brain and muscle was studied in rats poisoned with nitrostigmine. Haemodialysis was found to be quite an effective method for eliminating demeton-S-methyl sulfoxide and dimethoate, dialysance values of 52.98 ml/min and 59.07 ml/min being found for demeton-S-methyl sulfoxide and dimethoate respectively. Nitrostigmine could not be removed by haemodialysis. These findings suggest that haemodialysis could be of therapeutic value in the treatment of severe demeton-S-methyl sulfoxide and dimethoate poisoning in man. By blood exchange transfusion only 0.06% of the injected dose of nitrostigmine could be removed from the body of poisoned rats. Acetylcholinesterase activity increased only briefly in the period of blood exchange transfusion and decreased gradually afterwards. The enzymatic activity of brain and muscle was unaffected. Therefore, blood exchange transfusion has, if any at all, only poor therapeutic properties in nitrostigmine intoxication.
AuthorsS Okonek, G Boelcke, H Hollmann
JournalEuropean journal of intensive care medicine (Eur J Intensive Care Med) Vol. 2 Issue 1 Pg. 13-8 ( 1976) ISSN: 0340-0964 [Print] Germany
PMID954759 (Publication Type: Journal Article)
Chemical References
  • Organophosphorus Compounds
  • Sulfoxides
  • Parathion
  • Acetylcholinesterase
Topics
  • Acetylcholinesterase (metabolism)
  • Animals
  • Blood Transfusion
  • Organophosphate Poisoning
  • Organophosphorus Compounds (metabolism)
  • Parathion (metabolism)
  • Poisoning (therapy)
  • Rats
  • Renal Dialysis
  • Sulfoxides (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: