Fluorescence in situ hybridization reveals trisomy 2q by insertion into 9p in hepatoblastoma.

Abstract

Cytogenetics and fluorescence in situ hybridization (FISH) of a hepatoblastoma are presented. The results of standard chromosome analysis were as follows: 47,XY,+2,add(4)(q35),-9,+20[10]. FISH with the use of whole-chromosome paints revealed partial trisomy of the long arm of chromosome 2 by insertion into chromosome 9. Comparison of the G-banded metaphases with metaphase FISH led to a reinterpretation of the karyotype as: 47,XY,add(4)(q35),der(9)ins(9;2)(p22;q?21q?25),+20. This case supports previous observations that the critical region of trisomy 2 lies between 2q21 and 2qter and shows how partial trisomy 2q may evade detection in G-banded metaphases.

• Authors: E Balogh, S Swanton, C Kiss, Z S Jakab, L M Secker-Walker, E Oláh
• Journal: Cancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 102 Issue 2 Pg. 148-50 (Apr 15 1998) ISSN: 0165-4608 [Print] United States
• PMID: 9546070 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Child, Preschool
• Chromosome Banding
• Chromosomes, Human, Pair 2
• Chromosomes, Human, Pair 9
• Hepatoblastoma (genetics)
• Humans
• In Situ Hybridization, Fluorescence
• Karyotyping
• Liver Neoplasms (genetics)
• Male
• Trisomy