Digital subtraction indocyanine green angiography of occult choroidal neovascularization.

Abstract

OBJECTIVE:

This study aimed to use a new technique for ocular imaging, digital subtraction indocyanine green angiography (DS-ICGA), to evaluate patients with occult choroidal neovascularization (CNV).

DESIGN:

The design was a cross-sectional study of patients with occult CNV.

PARTICIPANTS:

A total of 31 eyes of 31 patients were studied.

INTERVENTION:

Digital subtraction of sequentially acquired indocyanine green angiographic frames was used to image the progression of the dye front in eyes with occult CNV. A method of pseudocolor imaging of the choroid was developed that allows differentiation and identification of underlying choroidal arteries and veins.

RESULTS:

The DS-ICGA of occult CNV showed consistent findings. Occult CNV was imaged with greater detail and in a shorter period of time than with conventional indocyanine green angiography. The fundus landmarks were retained with DS-ICGA much better than with conventional indocyanine green angiography.

CONCLUSIONS:

The DS-ICGA uses time to dissect the choroidal circulation. With DS-ICGA, occult CNV could be imaged more quickly and in greater detail than with conventional imaging techniques. The DS-ICGA may improve the authors ability to image, and subsequently treat, occult CNV.

• Authors: R F Spaide, D Orlock, L Yannuzzi, M Ruff, Y Fisher, D Guyer, J Slakter, J Sorenson
• Journal: Ophthalmology (Ophthalmology) Vol. 105 Issue 4 Pg. 680-8 (Apr 1998) ISSN: 0161-6420 [Print] United States
• PMID: 9544643 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fluorescent Dyes
• Indocyanine Green

Topics

• Angiography, Digital Subtraction (methods)
• Choroid (blood supply)
• Cross-Sectional Studies
• Fluorescein Angiography (methods)
• Fluorescent Dyes
• Fundus Oculi
• Humans
• Indocyanine Green
• Neovascularization, Pathologic (diagnosis)