Abstract | BACKGROUND: Limited Australian data are available on either short duration therapy for Helicobacter pylori infection, or the impact of metronidazole resistance on the outcome of treatment. AIM: To compare the efficacy of two treatment regimens and determine the influence metronidazole resistance has on clearing H. pylori infection. METHODS: RESULTS: On an intention-to-treat basis, clearance of infection was achieved in 17 of 32 (53%; 95% CI: 35-71%) evaluable patients receiving BTM and 32 of 46 (70%, 54-82%) patients receiving LAM (p = 0.16). Metronidazole resistance was found in 32 of 65 (49%) patients in whom H. pylori was isolated by culture. On a per-protocol basis, of patients who had metronidazole sensitive strains of H. pylori 23 of 24 (96%) cleared infection after therapy with either BTM or LAM, compared with 14 of 24 (58%) who were metronidazole resistant (p = 0.004). Clarithromycin resistance was not found in 45 patients tested. CONCLUSIONS: In Western Australia clearance rates of H. pylori infection, after one week of BTM or LAM, are lower than in other published series. The high incidence of metronidazole resistance is the main determinant of our relatively poor eradication rates.
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Authors | G M Forbes, B J Collins, C A McCullough, G W Coombs, P D Robins |
Journal | Australian and New Zealand journal of medicine
(Aust N Z J Med)
Vol. 28
Issue 1
Pg. 13-7
(Feb 1998)
ISSN: 0004-8291 [Print] Australia |
PMID | 9544380
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Anti-Bacterial Agents
- Penicillins
- Lansoprazole
- Metronidazole
- Amoxicillin
- Tetracycline
- Omeprazole
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Topics |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Adolescent
- Adult
- Aged
- Amoxicillin
(therapeutic use)
- Anti-Bacterial Agents
(pharmacology, therapeutic use)
- Drug Resistance, Microbial
- Drug Therapy, Combination
- Female
- Helicobacter Infections
(drug therapy, epidemiology)
- Helicobacter pylori
(drug effects)
- Humans
- Incidence
- Lansoprazole
- Male
- Metronidazole
(pharmacology, therapeutic use)
- Microbial Sensitivity Tests
- Middle Aged
- Omeprazole
(analogs & derivatives, therapeutic use)
- Penicillins
(therapeutic use)
- Tetracycline
(therapeutic use)
- Western Australia
(epidemiology)
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