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Lectin histochemistry in the aged dog brain.

Abstract
Formalin-fixed and paraffin-embedded canine brains were examined histochemically using 15 selected lectins. Concanavalin A (Con A), Lens culinaris agglutinin, Lycopersicon esculentum agglutinin (LEL) and Limulus polyphemus agglutinin (LPA) labeled neurons in an age-dependent manner. These and some other lectins [Dolichos biflorus agglutinin (DBA), Vicia villosa agglutinin (VVA), Ricinus communis agglutinin 120 (RCA-I), Bandeiraea simplicifolia agglutinin (BSL-I), and Phaseolus vulagaris agglutinin-L (PHA-L)] also age-dependently labeled glial cells. These results indicate that monosaccharide composition and biochemical metabolism in brain cells change with age and that these lectins may be useful as histochemical markers for investigating senile changes in the canine brain. However, no significant correlation was found between ApopTag-positive and lectin-positive cells. Amyloid plaques were positive for Con A, DBA, Glycine maximus agglutinin (SBA), LEL, PHA-L, Limax flavus agglutinin (LFA) and VVA. Among these lectins, VVA, SBA and LFA intensely stained amyloid both in blood vessel walls and senile plaque cores. Therefore, the sugar residues recognized by these lectins likely play specific roles in beta-amyloid deposition in the aged dog brain.
AuthorsW Kiatipattanasakul, H Nakayama, S Nakamura, K Doi
JournalActa neuropathologica (Acta Neuropathol) Vol. 95 Issue 3 Pg. 261-8 (Mar 1998) ISSN: 0001-6322 [Print] Germany
PMID9542591 (Publication Type: Journal Article)
Chemical References
  • Amyloid beta-Peptides
  • Lectins
Topics
  • Aging (pathology)
  • Amyloid beta-Peptides (analysis)
  • Animals
  • Brain (pathology)
  • Brain Chemistry (physiology)
  • Dogs
  • Lectins
  • Plaque, Amyloid (chemistry, pathology)

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