Free phenols in chronic renal failure.

Abstract

Serum total free phenols are elevated in chronic renal failure, acute renal failure and hepatic coma. Being partly protein-bound, phenols behave during dialysis in a similar manner to considerably larger molecules which are not protein-bound. In view of their potential toxicity they should be considered as an alternative to 'middle molecules'. Patients on regular hemodialysis have retention of phenols if their post-dialysis serum creatinine is above 6-7 mg/dl. Patients on short time dialysis have high pre-dialysis neutral phenol levels. Such levels are sufficiently high to suggest a role in the genesis of neurological symptoms, anemia and bone disease. Certainly pre-dialysis free phenols reflect adequacy of dialysis.

• Authors: E N Wardle, K Wilkinson
• Journal: Clinical nephrology (Clin Nephrol) Vol. 6 Issue 2 Pg. 361-4 (Aug 1976) ISSN: 0301-0430 [Print] Germany
• PMID: 954243 (Publication Type: Journal Article)

Chemical References

• Phenols
• Creatinine

Topics

• Acute Kidney Injury (blood)
• Creatinine (blood)
• Hepatic Encephalopathy (blood)
• Humans
• Kidney Failure, Chronic (blood, therapy)
• Phenols (blood)
• Renal Dialysis
• Time Factors