[Use of thymogen in the treatment of various forms of acute abdominal disorders in an experiment].

Abstract

The authors have carried out experimental studies of thymogen action on the course of acute pancreatitis and acute peritonitis in white albino rat males. The preparation was introduced into the abdominal cavity early after the modeling and every 24 hours for 5 days. The results of the trial demonstrate that the degree of autoenzyme aggression (the data of blood serum alpha-amylolytic activity control) and the content of lipid peroxidation products (assessment of malonic dialdehyde quantity in tissue homogenate) were low in the experimental group as compared to the untreated animals. In the experimental group less pronounced depression of antiradical activity (superoxide dismutase and catalase activity control) was found, leukocytosis and leukocyte intoxication index were diminished. Thus, the efficiency of thymogen in acute inflammatory and destructive abdominal diseases has been proved.

• Authors: K M Reznikov, O V Filippova, A A Glukhov, D V Griaznov, I N Banin
• Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia (Patol Fiziol Eksp Ter) 1998 Jan-Mar Issue 1 Pg. 17-9 ISSN: 0031-2991 [Print] Russia (Federation)
• Vernacular Title: Primenenie timogena v lechenii nekotorykh vidov ostroĭ abdominal'noĭ patologii v éksperimente.
• PMID: 9542399 (Publication Type: English Abstract, Journal Article)

Chemical References

• Dipeptides
• Peptides
• thymogen

Topics

• Acute Disease
• Animals
• Dipeptides
• Disease Models, Animal
• Male
• Pancreatitis (drug therapy)
• Peptides (therapeutic use)
• Peritonitis (drug therapy)
• Rats