Clinical study of [123I] N-(2-diethylaminoethyl)-4-iodobenzamide in the diagnosis of primary and metastatic ocular melanoma.

Abstract

PURPOSE:

To assess the value of scintigraphy with [123I]N-(2-diethylaminoethyl)-4-iodobenzamide (BZA), a phase II clinical trial was performed on 48 patients with a suspicion of ocular melanoma.

METHODS:

56 examinations were performed to image lesions with a clinical diagnosis of primary ocular melanoma before and/or after treatment, to observe the results in simulating lesions or to image metastases.

RESULTS:

Ocular BZA-scintigraphy demonstrated a sensitivity of 86%, and a specificity of 83%. Whole-body scintigraphy was used in the follow-up of treated patients and could be repeated. We imaged orbital recurrence, known and occult metastases, specially in the liver. After 9 conservative treatments ocular BZA-scintigraphy was negative in 9 eyes.

CONCLUSION:

The BZA-scintigraphy in combination with other diagnostic procedures appeared to be a suitable method in the diagnosis of ocular melanoma and a potentially useful imaging modality to screen for ocular malignant melanoma metastases.

• Authors: F Bacin, J Michelot, J Bonafous, A Veyre, M F Moreau, J L Kemeny, F Chossat, D Bekhechi
• Journal: Acta ophthalmologica Scandinavica (Acta Ophthalmol Scand) Vol. 76 Issue 1 Pg. 56-61 (Feb 1998) ISSN: 1395-3907 [Print] Denmark
• PMID: 9541435 (Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article)

Chemical References

• Benzamides
• Contrast Media
• N-(2-(diethylamino)ethyl)-4-iodobenzamide

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Benzamides
• Brachytherapy
• Conjunctival Neoplasms (diagnostic imaging, pathology, therapy)
• Contrast Media
• Eye Enucleation
• Female
• Humans
• Laser Coagulation
• Liver Neoplasms (diagnostic imaging, secondary, therapy)
• Lung Neoplasms (diagnostic imaging, secondary, therapy)
• Male
• Melanoma (diagnostic imaging, secondary, therapy)
• Middle Aged
• Radionuclide Imaging
• Sensitivity and Specificity
• Uveal Neoplasms (diagnostic imaging, pathology, therapy)