HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Studies on hyperthermia combined with arterial blockade for treatment of tumors: (Part II) effectiveness of hyperthermia combined with arterial embolization using degradable starch microspheres.

Abstract
The efficacy of temporary arterial embolization using degradable starch microspheres combined with hyperthermia was investigated in rabbits bearing VX2 tumors. Microsphere injection caused a marked decrease of tumor blood flow and pH. During heating, there was a marked increase of the maximum temperature in tumor tissue compared with normal muscle. Tumor growth was suppressed 330% times at 3 weeks after hyperthermia alone and 270% times following combined treatment with microspheres and hyperthermia. Damage to normal muscle tissue was mild. In conclusion, this combination therapy may be useful for causing selective tumor damage and reducing the effect on normal tissues.
AuthorsT Murata, K Akagi, M Imamura, R Nasu, H Kimura, K Nagata, Y Tanaka
JournalOncology reports (Oncol Rep) 1998 May-Jun Vol. 5 Issue 3 Pg. 705-8 ISSN: 1021-335X [Print] Greece
PMID9538180 (Publication Type: Journal Article)
Chemical References
  • Starch
Topics
  • Animals
  • Biodegradation, Environmental
  • Blood Flow Velocity
  • Cell Count (drug effects)
  • Combined Modality Therapy
  • Embolization, Therapeutic (methods)
  • Hydrogen-Ion Concentration
  • Hyperthermia, Induced
  • Iliac Artery (physiopathology)
  • Male
  • Microspheres
  • Muscle, Skeletal (blood supply)
  • Neoplasms, Experimental (blood supply, pathology, therapy)
  • Rabbits
  • Starch

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: