Effects of a 5-HT1A receptor agonist on acute and delayed cyclophosphamide-induced vomiting.

Abstract

LY228729 [(-)-4(dipropylamino)-1,3,4,5-tetrahydrobenz-[c,d]indole-6-carboxa mide]], an agonist at the 5-HT1A subtype of 5-HT receptor, was studied as an antiemetic in pigeons dosed with a highly emetic oncolytic agent, cyclophosphamide. An intramuscular injection of 0.32 mg/kg of LY228729 administered 15 min prior to the intravenous injection of 200 mg/kg of cyclophosphamide totally prevented the acute emetic response induced by cyclophosphamide. When used as a rescue therapy in a separate group of pigeons, LY228729 (0.32 mg/kg, i.m.) prevented further emetic episodes when it was administered after vomiting had already been induced by cyclophosphamide. Injections of LY228729 given at intervals over the next 2 d also attenuated the delayed emetic response induced by cyclophosphamide. LY228729 appears to be a broad spectrum antiemetic agent that is effective against the anticipatory, the acute and the delayed stages of emesis induced by oncolytic agents.

• Authors: M C Wolff, J D Leander
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 340 Issue 2-3 Pg. 217-20 (Dec 11 1997) ISSN: 0014-2999 [Print] Netherlands
• PMID: 9537818 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Alkylating
• Ergolines
• Serotonin Receptor Agonists
• LY 178210
• Cyclophosphamide

Topics

• Animals
• Antineoplastic Agents, Alkylating
• Columbidae
• Cyclophosphamide
• Ergolines (pharmacology)
• Male
• Serotonin Receptor Agonists (pharmacology)
• Vomiting (chemically induced, prevention & control)