Amlexanox oral paste: a novel treatment that accelerates the healing of aphthous ulcers.

Abstract

Five percent Amlexanox oral paste is a novel treatment for aphthous ulcers. In 3 controlled clinical studies that evaluated 1,124 immunocompetent patients with mild to moderate aphthous ulcers, 5% Amlexanox oral paste (Aphthasol) was shown to accelerate healing of these ulcers. Treatment with Aphthasol reduced the median time to ulcer healing and to complete pain resolution in a statistically significant manner. This was true both when treatment with 5% Amlexanox oral paste was compared to treatment with a vehicle and when treatment with the Amlexanox paste was compared to no treatment. Study results after 3 days comparing treatment with the paste and no treatment indicated complete healing of ulcers for 21% and 8% of patients, respectively. Complete resolution of pain after 3 days was reported for 44% and 20% of patients, respectively.

• Authors: W H Binnie, F A Curro, A Khandwala, R G Van Inwegan
• Journal: Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995) (Compend Contin Educ Dent) Vol. 18 Issue 11 Pg. 1116-8, 1120-2, 1124 passim (Nov 1997) ISSN: 1548-8578 [Print] United States
• PMID: 9533345 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Aminopyridines
• Anti-Inflammatory Agents
• amlexanox

Topics

• Administration, Topical
• Adult
• Aminopyridines (therapeutic use)
• Anti-Inflammatory Agents (therapeutic use)
• Chi-Square Distribution
• Double-Blind Method
• Female
• Humans
• Logistic Models
• Male
• Pain Measurement
• Stomatitis, Aphthous (drug therapy)