[Mechanism of action of nonachlazin on nervous regulation of coronary circulation].

Abstract

In experiments on cats and dogs under general anesthesia nonachlazine, a new antianginal agent, depressed the reflex decrease of the blood flow to the coronary arteries (electromagnetic recording). Nonachlazine also depressed the reflex decrease of the blood flow in the system of common carotic artery, and the pressure vasomotor reflexes. During recording the tonic and reflex activity in the heart sympathetic nerves nonachlazine proved to selectively inhibit the vasoconstrictor impulses from Adelta-afferent fibers of the spinal nerves, that is it influenced the vasomotor component of the "primary" pain reaction. This mechanism could underlie the block by nonachlazine of the pain syndrome during the heart ischemia disease.

• Authors: E A Bendikov, T S Gan'shina
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 81 Issue 3 Pg. 319-22 (Mar 1976) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: O mekhanizme deĭstviia nonakhlazina na nervnuiu reguliatsiiu koronarnogo krovoobrashcheniia
• PMID: 953279 (Publication Type: English Abstract, Journal Article)

Chemical References

• Phenothiazines
• Piperazines
• Vasodilator Agents

Topics

• Animals
• Carotid Arteries (innervation)
• Cats
• Coronary Circulation (drug effects)
• Coronary Vessels (innervation)
• Depression, Chemical
• Dogs
• Pain
• Phenothiazines (pharmacology)
• Piperazines (pharmacology)
• Reflex (drug effects)
• Spinal Nerves (physiology)
• Vasodilator Agents (pharmacology)
• Vasomotor System (drug effects)