Association of myelodysplastic changes with purine analogues.

Abstract

We describe the occurrence of myelodysplastic changes (hypogranular myeloid series and Pelger cells, dyserythropoiesis with ring sideroblasts) in five of 31 patients with chronic lymphoproliferative disorders after treatment with purine analogues. The bone marrows of 31 patients with chronic lymphoproliferative disorders before and after treatment with purine analogues were reviewed. The majority of patients had received extensive prior treatment, but none had dysplastic changes prior to treatment with purine analogues. We suggest that a purine analogue may have been responsible for dysplastic change and that further follow-up of this phenomenon is warranted.

• Authors: J A Orchard, S Bolam, D G Oscier
• Journal: British journal of haematology (Br J Haematol) Vol. 100 Issue 4 Pg. 677-9 (Mar 1998) ISSN: 0007-1048 [Print] England
• PMID: 9531333 (Publication Type: Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Antimetabolites, Antineoplastic
• Antineoplastic Agents
• Deoxyadenosines
• 2-Chloroadenosine
• Pentostatin
• Vidarabine
• 2-chloro-3'-deoxyadenosine
• fludarabine

Topics

• 2-Chloroadenosine (adverse effects, analogs & derivatives)
• Antibiotics, Antineoplastic (adverse effects)
• Antimetabolites, Antineoplastic (adverse effects)
• Antineoplastic Agents (adverse effects)
• Deoxyadenosines (adverse effects)
• Female
• Humans
• Lymphoproliferative Disorders (drug therapy)
• Male
• Myelodysplastic Syndromes (chemically induced)
• Pentostatin (adverse effects)
• Vidarabine (adverse effects, analogs & derivatives)