Lack of inhibitory effect of octreotide on intestinal adaptation in short bowel syndrome in the rat.

Abstract

BACKGROUND:

Octreotide is a long-acting analogue of somatostatin, which is effective in the treatment of secretory diarrhea in a number of disorders including short bowel syndrome. Its use in this syndrome has been limited because of concerns about potential adverse effect on intestinal adaptation, because it inhibits a number of trophic hormones. This study was conducted to determine whether octreotide inhibits intestinal adaptation in a rat model of short bowel syndrome.

METHODS:

Thirty male Sprague-Dawley rats were divided into four treatment groups, eight receiving 80% small-bowel resection and treated with 2.25 microg/kg(-1) per day(-1) of octreotide, eight receiving 80% small-bowel resection and treated with 25 microg/kg(-1) per day(-1) of octreotide, eight receiving 80% small-bowel resection with saline control, and six receiving sham operation with saline control. Mucosal weight, protein, and sucrase levels were subsequently analyzed after 2 weeks of therapy.

RESULTS:

Massive adaptation occurred in all three groups relative to sham-operated controls. However, neither the pharmacologic nor the much higher dose of octreotide demonstrated any adverse effects on intestinal adaptation.

CONCLUSION:

In our animal model, octreotide does not inhibit intestinal adaptation after massive small-bowel resection.

• Authors: J A Vanderhoof, K A Kollman
• Journal: Journal of pediatric gastroenterology and nutrition (J Pediatr Gastroenterol Nutr) Vol. 26 Issue 3 Pg. 241-4 (Mar 1998) ISSN: 0277-2116 [Print] United States
• PMID: 9523855 (Publication Type: Journal Article)

Chemical References

• Proteins
• Sucrase
• Octreotide

Topics

• Adaptation, Physiological (drug effects)
• Animals
• Duodenum (metabolism, pathology)
• Ileum (metabolism, pathology)
• Intestinal Mucosa (metabolism, pathology)
• Intestines (drug effects, physiopathology)
• Male
• Octreotide (adverse effects, therapeutic use)
• Proteins (metabolism)
• Rats
• Rats, Sprague-Dawley
• Short Bowel Syndrome (drug therapy, physiopathology)
• Sucrase (metabolism)