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Abnormal cholesterol biosynthesis produced by AY 9944 in the rat leads to skeletal deformities similar to the Smith-Lemli-Opitz syndrome.

AuthorsA K Batta, G Salen
JournalThe Journal of laboratory and clinical medicine (J Lab Clin Med) Vol. 131 Issue 3 Pg. 192-3 (Mar 1998) ISSN: 0022-2143 [Print] United States
PMID9523840 (Publication Type: Comment, Editorial, Review)
Chemical References
  • Anticholesteremic Agents
  • Enzyme Inhibitors
  • trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride
  • Cholesterol
  • Oxidoreductases
  • Oxidoreductases Acting on CH-CH Group Donors
  • 7-dehydrocholesterol reductase
Topics
  • Abnormalities, Drug-Induced
  • Animals
  • Anticholesteremic Agents (toxicity)
  • Bone Development (drug effects)
  • Bone and Bones (abnormalities)
  • Cholesterol (biosynthesis)
  • Enzyme Inhibitors (toxicity)
  • Female
  • Holoprosencephaly (chemically induced)
  • Humans
  • Oxidoreductases (antagonists & inhibitors)
  • Oxidoreductases Acting on CH-CH Group Donors
  • Pregnancy
  • Rats
  • Smith-Lemli-Opitz Syndrome (etiology, metabolism)
  • trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride (toxicity)

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