[Prospective randomized pilot study of ambulatory prevention of thromboembolism. 2 times 500 mg aspirin (ASS) vs. clivarin 1750 (NMH)].

Abstract

From March 1994 to March 1996, 287 patients, presenting with lower extremity injuries, who required immobilizing bandages or casts, where included in a prospective, randomized study. These patients received either low-molecular heparin or acetylsalicylic acid for thrombosis prophylaxis. In all patients a clinical examination and a colour-coded duplex sonography were performed after removal of the cast for detection of lower extremity venous thrombosis. A plebography was performed when thrombosis was suspected. A subcutaneous injection of divarin 1750 was given once daily in 143 patients. Thrombosis prophylaxis with Aspirin 2 x 500 mg administered orally was performed in 144 patients. Deep vein thrombosis occurred in 9 patients (6.3%) with clivarin prophylaxis and in 7 patients (4.8%) treated with Aspirin. In both groups, no clinically significant side effects of the medications were observed.

• Authors: H Gehling, K Giannadakis, R Lefering, M Hessmann, S Achenbach, L Gotzen
• Journal: Der Unfallchirurg (Unfallchirurg) Vol. 101 Issue 1 Pg. 42-9 (Jan 1998) ISSN: 0177-5537 [Print] Germany
• Vernacular Title: Prospektiv-randomisierte Pilotstudie zur ambulanten Thromboembolieprophylaxe. 2 mal 500 mg Aspirin (ASS) vs. Clivarin 1750 (NMH).
• PMID: 9522671 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anticoagulants
• Heparin, Low-Molecular-Weight
• reviparin
• Aspirin

Topics

• Adult
• Aged
• Ambulatory Care
• Anticoagulants (administration & dosage)
• Aspirin (administration & dosage)
• Casts, Surgical
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Female
• Heparin, Low-Molecular-Weight (administration & dosage)
• Humans
• Leg Injuries (complications, therapy)
• Male
• Middle Aged
• Pilot Projects
• Prospective Studies
• Thromboembolism (prevention & control)