Electrolytic lesion of globus pallidus ameliorates the behavioral and neurodegenerative effects of quinolinic acid lesion of the striatum: a potential novel treatment in a rat model of Huntington's disease.

Abstract	Bilateral electrolytic pallidal lesion ameliorated the deleterious effects of bilateral quinolinic acid (QA) lesion to the striatum on post-surgery weight, activity level, and performance in a water maze task, and reduced the extent of striatal damage. Given that the neurodegenerative and behavioral effects of QA striatal lesion are thought to mimic those seen in Huntington's disease, these results may point to a potential novel treatment for this disease.
Authors	D Joel, L Ayalon, R Tarrasch, L Veenman, J Feldon, I Weiner
Journal	Brain research (Brain Res) Vol. 787 Issue 1 Pg. 143-8 (Mar 16 1998) ISSN: 0006-8993 [Print] Netherlands
PMID	9518584 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright	Copyright 1998 Elsevier Science B.V.
Chemical References	Quinolinic Acid
Topics	Animals Corpus Striatum (drug effects, pathology) Disease Models, Animal Electrolysis Globus Pallidus (physiology) Huntington Disease (pathology, therapy) Male Maze Learning (physiology) Motor Activity (physiology) Nerve Degeneration (physiopathology) Quinolinic Acid (toxicity) Rats Rats, Wistar

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