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Prevention of nausea and vomiting in female patients undergoing breast surgery: a comparison with granisetron, droperidol, metoclopramide and placebo.

AbstractBACKGROUND:
Breast surgery is associated with a relatively high incidence of postoperative nausea and vomiting (PONV). This study was undertaken to evaluate the efficacy of granisetron, droperidol and metoclopramide for preventing PONV after breast surgery.
METHODS:
In a randomized, double-blind, placebo-controlled trial, 120 female patients received granisetron 40 micrograms.kg-1, droperidol 1.25 mg, metoclopramide 10 mg or placebo (saline) (n = 30 for each) intravenously immediately before the induction of anaesthesia. A standard general anaesthetic technique was employed throughout. Postoperatively, during the first 24 h after anaesthesia, the incidence of PONV and adverse events was recorded.
RESULTS:
The incidence of PONV was 17% with granisetron, 37% with droperidol, 43% with metoclopramide and 50% with placebo (P < 0.05; overall Fisher's exact probability test). The incidence of adverse events was not different among the groups.
CONCLUSION:
Granisetron is highly effective for reducing the incidence of PONV in female patients undergoing breast surgery. Droperidol and metoclopramide are ineffective in this population.
AuthorsY Fujii, H Tanaka, H Toyooka
JournalActa anaesthesiologica Scandinavica (Acta Anaesthesiol Scand) Vol. 42 Issue 2 Pg. 220-4 (Feb 1998) ISSN: 0001-5172 [Print] DENMARK
PMID9509207 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Retracted Publication)
Chemical References
  • Antiemetics
  • Metoclopramide
  • Droperidol
  • Granisetron
Topics
  • Adult
  • Antiemetics (therapeutic use)
  • Breast Neoplasms (surgery)
  • Double-Blind Method
  • Droperidol (therapeutic use)
  • Female
  • Granisetron (therapeutic use)
  • Humans
  • Metoclopramide (therapeutic use)
  • Middle Aged
  • Nausea (prevention & control)
  • Postoperative Complications (prevention & control)
  • Vomiting (prevention & control)

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