Oral phentolamine as treatment for erectile dysfunction.

Abstract

PURPOSE:

For most patients with erectile dysfunction oral agents are a preferred treatment option. Oral or buccal phentolamine has been shown to produce full erections in impotent subsets of study populations. We evaluate the efficacy of oral phentolamine.

MATERIALS AND METHODS:

After a comprehensive evaluation 44 patients with recent onset (less than 3 years) of erectile dysfunction and a high likelihood of organogenic etiology underwent a prospective, double-blind and placebo controlled trial with oral phentolamine after placebo.

RESULTS:

After placebo 4 of the 44 patients who reported full erections were excluded from study. Of the 40 patients in the double-blind phase full erections were achieved by 2 of 10 with placebo, and 3 of 10 with 20 mg., 5 of 10 with 40 mg. and 4 of 10 with 60 mg. phentolamine. There were no serious complications observed during the study, and only a single minor side effect occurred in 1 patient after 60 mg. phentolamine.

CONCLUSIONS:

Our results indicate that oral phentolamine may be of benefit for the treatment of erectile dysfunction. Further studies are required to corroborate our findings.

• Authors: A J Becker, C G Stief, S Machtens, D Schultheiss, U Hartmann, M C Truss, U Jonas
• Journal: The Journal of urology (J Urol) Vol. 159 Issue 4 Pg. 1214-6 (Apr 1998) ISSN: 0022-5347 [Print] United States
• PMID: 9507837 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenergic alpha-Antagonists
• Phentolamine

Topics

• Administration, Oral
• Adrenergic alpha-Antagonists (administration & dosage)
• Adult
• Aged
• Double-Blind Method
• Erectile Dysfunction (drug therapy)
• Humans
• Middle Aged
• Phentolamine (administration & dosage)
• Prospective Studies