A case of canine central nervous system cryptococcosis: management with fluconazole.

Abstract

A three-year-old, female Labrador retriever was presented for acute generalized seizures. Disseminated cryptococcosis with central nervous system (CNS) involvement was diagnosed by serum and cerebrospinal fluid (CSF) fungal titers, histopathological examination, and magnetic resonance imaging (MRI). Fluconazole therapy resulted in prolonged, substantial clinical improvement for a period of one year. This report documents the diagnosis of a case of cryptococcal meningoencephalitis and its management with the new antifungal agent, fluconazole.

• Authors: D Tiches, C H Vite, B Dayrell-Hart, S A Steinberg, S Gross, F Lexa
• Journal: Journal of the American Animal Hospital Association (J Am Anim Hosp Assoc) 1998 Mar-Apr Vol. 34 Issue 2 Pg. 145-51 ISSN: 0587-2871 [Print] United States
• PMID: 9507427 (Publication Type: Case Reports, Comparative Study, Journal Article)

Chemical References

• Antifungal Agents
• Fluconazole

Topics

• Animals
• Antifungal Agents (blood, metabolism, therapeutic use)
• Central Nervous System (microbiology, pathology)
• Cryptococcosis (diagnosis, drug therapy, veterinary)
• Dog Diseases (diagnostic imaging, drug therapy)
• Dogs
• Female
• Fluconazole (blood, metabolism, therapeutic use)
• Magnetic Resonance Imaging
• Meningoencephalitis (diagnosis, drug therapy, veterinary)
• Radiography
• Time Factors