HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Susceptibility to skin stinging, non-immunologic contact urticaria and acute skin irritation; is there a relationship?

Abstract
Adverse skin reactions cover many types of response: toxic, irritant, allergic, urticarial, sensory, etc. The relationships between an individual's tendency to develop different types of skin response are not well-described. We examined whether those who perceive stinging might be more likely to experience urticarial, sensory and irritation reactions in skin. A panel of 86 volunteers was tested with 10% lactic acid in the nasolabial fold to assess their ability to perceive stinging. At the same time, their capacity to develop non-immunologic contact urticaria was evaluated using chemicals of different structural type and urticant ability: methyl nicotinate, benzoic acid, cinnamic acid, cinnamaldehyde and dimethyl sulfoxide (DMSO). DMSO was also used to assess sensory effects and skin irritation. 44 were classes as "stingers" and 42 as "non-stingers". The pattern of urticant reactivity in the stingers and non-stingers was essentially the same, with neat DMSO generating the strongest reactions in both groups. Sensory reactions to DMSO (stinging, itching, tingling or burning) were similar in stingers and non-stingers; although the former may have reacted more quickly, a smaller proportion reacted (64% versus 76%). The skin irritation response to DMSO was also identical in stingers and non-stingers and the intensity of the urticant response in an individual did not correlate with the intensity of their subsequent irritant reaction. In conclusion, this study demonstrated that an individual's ability to perceive skin stinging does not give a general indication of their susceptibility to other types of non-immunologic skin response. Indeed, there appeared to be little evidence of correlations between any of the skin effects studied.
AuthorsJ Coverly, L Peters, E Whittle, D A Basketter
JournalContact dermatitis (Contact Dermatitis) Vol. 38 Issue 2 Pg. 90-5 (Feb 1998) ISSN: 0105-1873 [Print] England
PMID9506221 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Antimutagenic Agents
  • Benzoates
  • Cinnamates
  • Food Preservatives
  • Nicotinic Acids
  • cinnamic acid
  • Lactic Acid
  • Acrolein
  • methyl nicotinate
  • Benzoic Acid
  • cinnamaldehyde
  • Dimethyl Sulfoxide
Topics
  • Acrolein (administration & dosage, adverse effects, analogs & derivatives)
  • Acute Disease
  • Administration, Topical
  • Adult
  • Anti-Inflammatory Agents (administration & dosage, adverse effects)
  • Antimutagenic Agents (administration & dosage, adverse effects)
  • Benzoates (administration & dosage, adverse effects)
  • Benzoic Acid
  • Cinnamates (administration & dosage, adverse effects)
  • Dermatitis, Contact (etiology, physiopathology)
  • Dermatitis, Irritant (etiology, physiopathology)
  • Dimethyl Sulfoxide (administration & dosage, adverse effects)
  • Disease Susceptibility
  • Erythema (chemically induced)
  • Female
  • Food Preservatives (administration & dosage, adverse effects)
  • Humans
  • Lactic Acid (administration & dosage, adverse effects)
  • Male
  • Middle Aged
  • Nicotinic Acids (administration & dosage, adverse effects)
  • Patch Tests
  • Severity of Illness Index
  • Skin Diseases (etiology, physiopathology)
  • Surveys and Questionnaires
  • Urticaria (etiology, physiopathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: