Abstract | BACKGROUND: AIMS: To investigate the circulating concentrations of beta hCG in patients with exocrine pancreatic adenocarcinoma and to examine its potential prognostic value. PATIENTS: METHODS: beta hCG serum concentrations were detected by the application of a radioimmunoassay technique. RESULTS: Fifteen of 36 patients with pancreatic adenocarcinoma and only one patient with chronic pancreatitis had detectable plasma concentrations of beta hCG (p < 0.01). The patients with circulating serum titres of beta hCG had a worse outcome compared with the group of beta hCG negative patients: the difference was statistically significant (p = 0.01). CONCLUSION: More than 40% of pancreatic exocrine tumours produce beta hCG and its production is correlated with an adverse effect on outcome.
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Authors | K N Syrigos, I Fyssas, M M Konstandoulakis, K J Harrington, S Papadopoulos, N Milingos, P Peveretos, B C Golematis |
Journal | Gut
(Gut)
Vol. 42
Issue 1
Pg. 88-91
(Jan 1998)
ISSN: 0017-5749 [Print] England |
PMID | 9505891
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Chorionic Gonadotropin, beta Subunit, Human
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Topics |
- Adenocarcinoma
(blood, mortality)
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(blood)
- Chi-Square Distribution
- Chorionic Gonadotropin, beta Subunit, Human
(blood)
- Chronic Disease
- Female
- Humans
- Male
- Middle Aged
- Pancreatic Neoplasms
(blood, mortality)
- Pancreatitis
(blood)
- Prognosis
- Survival Rate
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