Lysine clonixinate vs. paracetamol/codeine in postepisiotomy pain.

Abstract

This study was conducted to compare the analgesic action of Lysine Clonixinate (LC) vs Paracetamol/Codeine association (PC) in the treatment of postepisiotomy pain in primiparae women: 131 primiparous patients with moderate-to-severe postepisiotomy pain were enrolled in a double blind dummy design study and randomly allocated to either treatment with fixed doses of LC 125 mg or Paracetamol 500 mg+Codeine 30 mg 6 qh during 24 hours. Intensity of spontaneous pain and pain on walking was assessed according to a visual analog scale (VAS) and patient's assessment before receiving treatment and after 1, 2, 6 and 24 hours. Intensity of spontaneous pain was reduced in 24 hours from 4.28 +/- 2.11 to 1.73 +/- 1.46 (P < 0.0001) in the LC group and from 4.78 +/- 2.08 to 1.90 +/- 1.72 in the PC-treated group (p < 0.0001); with no significant differences between treatments. 54% of the patients treated with LC and 55% of those receiving PC showed onset of analgesic action 30 minutes following dose administration. Patient's final global assessment revealed that 95% of LC-treated patients and 96% of the PC group showed total or partial pain relief during the first treatment day. No sleep disturbances were seen during the night in 75% of patients. Only one patient receiving LC showed nausea not requiring treatment discontinuation. It is concluded that both treatments are equally effective to relieve moderate-to-severe postepisiotomy pain.

• Authors: A R De los Santos, M I Martí, D Espinosa, G Di Girolamo, J C Vinacur, A Casadei
• Journal: Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia (Acta Physiol Pharmacol Ther Latinoam) Vol. 48 Issue 1 Pg. 52-8 ( 1998) ISSN: 0327-6309 [Print] Argentina
• PMID: 9504193 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Analgesics
• lysine clonixinate
• Acetaminophen
• Lysine
• Codeine
• Clonixin

Topics

• Acetaminophen (therapeutic use)
• Adult
• Analgesics (therapeutic use)
• Analysis of Variance
• Clonixin (analogs & derivatives, therapeutic use)
• Codeine (therapeutic use)
• Double-Blind Method
• Episiotomy (adverse effects)
• Female
• Humans
• Lysine (analogs & derivatives, therapeutic use)
• Pain, Postoperative (drug therapy)
• Time Factors