The value of methylprednisolone in the treatment of an experimental sensorineural hearing loss following drill-induced ossicular chain injury: a randomized, blinded study in guinea-pigs.

Abstract

In a previously established animal model a standardized drill-induced injury to the body of the incus was applied, and the effects on hearing were characterized by electrocochleography. In a placebo-controlled, randomized, blinded study methylprednisolone showed no protective effect in reducing or improving the auditory threshold shifts, which occurred within seconds after drilling and remained stable throughout the 5-week observation period. Therefore the otologic surgeon must pay close attention to avoiding any contact of a rotating burr with an ossicle in an intact ossicular chain.

• Authors: W Schneider, M Gjuric, A Katalinic, W Buhr, S R Wolf
• Journal: Acta oto-laryngologica (Acta Otolaryngol) Vol. 118 Issue 1 Pg. 52-5 (Jan 1998) ISSN: 0001-6489 [Print] England
• PMID: 9504163 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents
• Methylprednisolone

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology)
• Audiometry, Evoked Response
• Auditory Fatigue (drug effects)
• Double-Blind Method
• Drug Administration Schedule
• Guinea Pigs
• Hearing Loss, Sensorineural (physiopathology)
• Incus (drug effects, injuries, physiopathology)
• Injections, Intraperitoneal
• Intraoperative Complications (physiopathology)
• Methylprednisolone (pharmacology)
• Surgical Instruments