Abstract |
In a previously established animal model a standardized drill-induced injury to the body of the incus was applied, and the effects on hearing were characterized by electrocochleography. In a placebo-controlled, randomized, blinded study methylprednisolone showed no protective effect in reducing or improving the auditory threshold shifts, which occurred within seconds after drilling and remained stable throughout the 5-week observation period. Therefore the otologic surgeon must pay close attention to avoiding any contact of a rotating burr with an ossicle in an intact ossicular chain.
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Authors | W Schneider, M Gjuric, A Katalinic, W Buhr, S R Wolf |
Journal | Acta oto-laryngologica
(Acta Otolaryngol)
Vol. 118
Issue 1
Pg. 52-5
(Jan 1998)
ISSN: 0001-6489 [Print] England |
PMID | 9504163
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Inflammatory Agents
- Methylprednisolone
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Audiometry, Evoked Response
- Auditory Fatigue
(drug effects)
- Double-Blind Method
- Drug Administration Schedule
- Guinea Pigs
- Hearing Loss, Sensorineural
(physiopathology)
- Incus
(drug effects, injuries, physiopathology)
- Injections, Intraperitoneal
- Intraoperative Complications
(physiopathology)
- Methylprednisolone
(pharmacology)
- Surgical Instruments
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