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[GABA-ergic system in defense against excitatory kynurenines].

Abstract
Protection against the excitatory action of L-kynurenine and quinolinic acid in mice is related to the activation of GABA-B and dopamine receptors of the brain and to much lesser degree to the activation of GABA-A receptors. It is hardly believable that the anticonvulsant effect of phenibut (beta-phenyl-GABA), baclofen (CL-phenibut), sodium hydroxybutyrate and taurine against seizures induced by these two kynurenines is determined by alterations in metabolism of GABA.
AuthorsI P Lapin
JournalVoprosy meditsinskoi khimii (Vopr Med Khim) 1997 Nov-Dec Vol. 43 Issue 6 Pg. 548-52 ISSN: 0042-8809 [Print] Russia (Federation)
Vernacular TitleGAMK-ergicheskaia sistema v zashchite ot vozbuzhdaiushchikh kinureninov.
PMID9503572 (Publication Type: Journal Article)
Chemical References
  • Anticonvulsants
  • Dopamine Agonists
  • GABA-A Receptor Agonists
  • GABA-B Receptor Agonists
  • Hydroxybutyrates
  • Taurine
  • Kynurenine
  • gamma-Aminobutyric Acid
  • Quinolinic Acid
  • Baclofen
  • 4-amino-3-phenylbutyric acid
Topics
  • Animals
  • Anticonvulsants (pharmacology)
  • Baclofen (pharmacology)
  • Brain (drug effects, metabolism)
  • Dopamine Agonists (pharmacology)
  • GABA-A Receptor Agonists
  • GABA-B Receptor Agonists
  • Hydroxybutyrates (pharmacology)
  • Injections, Intraventricular
  • Kynurenine (administration & dosage, toxicity)
  • Male
  • Mice
  • Quinolinic Acid (administration & dosage, toxicity)
  • Taurine (pharmacology)
  • gamma-Aminobutyric Acid (analogs & derivatives, metabolism, pharmacology, physiology)

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