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Subcellular localization of Bcl-2 protein in synovial sarcoma.

Abstract
The subcellular localization of Bcl-2 protein in surgically resected, fixed-frozen tissue specimens of seven tumors from six cases of synovial sarcoma and a synovial sarcoma cell line was examined using laser-scanning confocal microscopy and immunoelectron microscopy. Bcl-2 protein in synovial sarcoma cells was detected in the nuclear envelope, endoplasmic reticulum membrane, and mitochondrial circumference. Based on the finding of pre-embedding immunoelectron-microscopy observation, the distribution of Bcl-2 protein in such membranous organella was patchy. A computer-based image analysis failed to reveal any quantitative differences between the inner and the outer mitochondrial membranes. The tumorigenesis of synovial sarcoma is also discussed from the viewpoint of Bcl-2 overexpression.
AuthorsS Kawauchi, S Noguchi, T Fukuda, M Tsuneyoshi
JournalPathology international (Pathol Int) Vol. 47 Issue 12 Pg. 854-61 (Dec 1997) ISSN: 1320-5463 [Print] Australia
PMID9503467 (Publication Type: Journal Article)
Chemical References
  • Proto-Oncogene Proteins c-bcl-2
Topics
  • Adult
  • Blotting, Western
  • Female
  • Fluorescent Antibody Technique, Indirect
  • Humans
  • Immunohistochemistry
  • Male
  • Microscopy, Confocal
  • Microscopy, Immunoelectron
  • Middle Aged
  • Proto-Oncogene Proteins c-bcl-2 (metabolism)
  • Sarcoma, Synovial (metabolism, ultrastructure)
  • Tumor Cells, Cultured

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