U-43,120; a new antitumor antibiotic. I. Production, biological activity, microbiological assay and taxonomy of the producing microorganism.

Abstract	A new antitumor antibiotic, U-43,120 was discovered. It is produced by fermentation of a new species of Streptomyces, designated Streptomyces paulus DIETZ sp. n. Its antimicrobial activity is limited to bacteria. A microbiological assay with Bacillus subtilis was developed that can be detect concentrations of 1 approximately 2 mug/ml of the drug in fermentation liquors. U-43,120 was active in vivo against P-388 leukemia in mice.
Authors	L J Hanka, A Dietz
Journal	The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 29 Issue 6 Pg. 611-7 (Jun 1976) ISSN: 0021-8820 [Print] England
PMID	950315 (Publication Type: Journal Article)
Chemical References	Antibiotics, Antineoplastic
Topics	Animals Antibiotics, Antineoplastic (biosynthesis, pharmacology, therapeutic use) Bacteria (drug effects) Fermentation Leukemia, Experimental (drug therapy) Mice Streptomyces (classification, growth & development, metabolism) Time Factors

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