Delusional disorder in a boy with phenylketonuria and amine metabolites in the cerebrospinal fluid after treatment with neuroleptics.

Abstract

A case report of a 16-year-old boy with the classical form of phenylketonuria (PKU) and suffering from a delusional disorder is presented. He did not respond to a traditional antipsychotic medication but improved on an atypical antipsychotic, risperidone. The cerebrospinal fluid metabolites of the biogenic amines were measured and are also reported in the context of a recent interest in the ratios of these amine metabolites in schizophrenia. It is proposed that such dually diagnosed patients with PKU may provide a model in which to test the prevalent biogenic amine theories in psychiatric disorders.

• Authors: R S Shiwach, S Sheikha
• Journal: The Journal of adolescent health : official publication of the Society for Adolescent Medicine (J Adolesc Health) Vol. 22 Issue 3 Pg. 244-6 (Mar 1998) ISSN: 1054-139X [Print] United States
• PMID: 9502013 (Publication Type: Case Reports, Journal Article)

Chemical References

• Amines
• Phenylalanine

Topics

• Adolescent
• Amines (cerebrospinal fluid, metabolism)
• Humans
• Male
• Phenylalanine (blood)
• Phenylketonurias (complications)
• Schizophrenia, Paranoid (cerebrospinal fluid, complications)