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Delusional disorder in a boy with phenylketonuria and amine metabolites in the cerebrospinal fluid after treatment with neuroleptics.

Abstract
A case report of a 16-year-old boy with the classical form of phenylketonuria (PKU) and suffering from a delusional disorder is presented. He did not respond to a traditional antipsychotic medication but improved on an atypical antipsychotic, risperidone. The cerebrospinal fluid metabolites of the biogenic amines were measured and are also reported in the context of a recent interest in the ratios of these amine metabolites in schizophrenia. It is proposed that such dually diagnosed patients with PKU may provide a model in which to test the prevalent biogenic amine theories in psychiatric disorders.
AuthorsR S Shiwach, S Sheikha
JournalThe Journal of adolescent health : official publication of the Society for Adolescent Medicine (J Adolesc Health) Vol. 22 Issue 3 Pg. 244-6 (Mar 1998) ISSN: 1054-139X [Print] UNITED STATES
PMID9502013 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Amines
  • Phenylalanine
Topics
  • Adolescent
  • Amines (cerebrospinal fluid, metabolism)
  • Humans
  • Male
  • Phenylalanine (blood)
  • Phenylketonurias (complications)
  • Schizophrenia, Paranoid (cerebrospinal fluid, complications)

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