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Induction of Arabidopsis tryptophan pathway enzymes and camalexin by amino acid starvation, oxidative stress, and an abiotic elicitor.

Abstract
The tryptophan (Trp) biosynthetic pathway leads to the production of many secondary metabolites with diverse functions, and its regulation is predicted to respond to the needs for both protein synthesis and secondary metabolism. We have tested the response of the Trp pathway enzymes and three other amino acid biosynthetic enzymes to starvation for aromatic amino acids, branched-chain amino acids, or methionine. The Trp pathway enzymes and cytosolic glutamine synthetase were induced under all of the amino acid starvation test conditions, whereas methionine synthase and acetolactate synthase were not. The mRNAs for two stress-inducible enzymes unrelated to amino acid biosynthesis and accumulation of the indolic phytoalexin camalexin were also induced by amino acid starvation. These results suggest that regulation of the Trp pathway enzymes under amino acid deprivation conditions is largely a stress response to allow for increased biosynthesis of secondary metabolites. Consistent with this hypothesis, treatments with the oxidative stress-inducing herbicide acifluorfen and the abiotic elicitor alpha-amino butyric acid induced responses similar to those induced by the amino acid starvation treatments. The role of salicylic acid in herbicide-mediated Trp and camalexin induction was investigated.
AuthorsJ Zhao, C C Williams, R L Last
JournalThe Plant cell (Plant Cell) Vol. 10 Issue 3 Pg. 359-70 (Mar 1998) ISSN: 1040-4651 [Print] England
PMID9501110 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Amino Acids
  • Aminobutyrates
  • Herbicides
  • Indoles
  • Nitrobenzoates
  • RNA, Messenger
  • Salicylates
  • Thiazoles
  • camalexin
  • alpha-aminobutyric acid
  • Tryptophan
  • 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
  • Acetolactate Synthase
  • Glutamate-Ammonia Ligase
  • Salicylic Acid
  • acifluorfen
Topics
  • 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase (metabolism)
  • Acetolactate Synthase (metabolism)
  • Amino Acids (metabolism)
  • Aminobutyrates (pharmacology)
  • Arabidopsis (drug effects, enzymology, metabolism)
  • Glutamate-Ammonia Ligase (metabolism)
  • Heat-Shock Response
  • Herbicides (pharmacology)
  • Indoles (metabolism)
  • Nitrobenzoates (pharmacology)
  • Oxidative Stress
  • RNA, Messenger (metabolism)
  • Salicylates (metabolism)
  • Salicylic Acid
  • Thiazoles (metabolism)
  • Tryptophan (biosynthesis)

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