Abstract | OBJECTIVE: Our purpose was to assess the effects of an intravenous dose of a highly selective mu-( DALDA) and delta-( DPDPE) opioid peptide to determine which class of peptide has the best clinical potential. STUDY DESIGN: Chronically instrumented pregnant ewes received a 0.3 mg/kg intravenous bolus of each peptide with and without opioid receptor blockade by means of a randomized prospective design. RESULTS: CONCLUSION: The delta-selective agonist had multiple nonopioid adverse effects, whereas the mu-selective agonist was well tolerated by the pregnant ewe, suggesting that mu-selective agonists have better potential for clinical use as an analgesic in pregnancy.
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Authors | J F Clapp 3rd, A Kett, N Olariu, A T Omoniyi, D Wu, H Kim, H H Szeto |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 178
Issue 2
Pg. 397-401
(Feb 1998)
ISSN: 0002-9378 [Print] United States |
PMID | 9500506
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Blood Glucose
- Enkephalins
- Oligopeptides
- Receptors, Opioid, delta
- Receptors, Opioid, mu
- tyrosyl-arginyl-phenylalanyl-lysinamide
- Enkephalin, D-Penicillamine (2,5)-
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Topics |
- Animals
- Blood Glucose
(metabolism)
- Blood Pressure
(drug effects)
- Cardiovascular System
(drug effects, physiopathology)
- Enkephalin, D-Penicillamine (2,5)-
- Enkephalins
(administration & dosage, pharmacology)
- Female
- Fetus
(drug effects)
- Heart Rate
(drug effects)
- Oligopeptides
(administration & dosage, pharmacology)
- Oxygen Consumption
(drug effects)
- Pregnancy
- Receptors, Opioid, delta
(agonists)
- Receptors, Opioid, mu
(agonists)
- Respiration
(drug effects)
- Sheep
- Uterus
(blood supply)
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