Abstract | OBJECTIVE: STUDY DESIGN: RESULTS AND CONCLUSIONS: The newly developed derivative of raloxifene, LY-117018 HCl, offsets the reduction in bone mineral density and the accompanying increase in bone remodeling markers observed in oophorectomized rats compared with control animals. 17Alpha-ethinyl estradiol also prevents the loss of bone mass attributed to oophorectomy, but this is accompanied by an increase in body mass and a greater increase in uterus weight than that observed after treatment with LY-117018 HCl.
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Authors | M D Curiel, J A Calero, R Guerrero, J Gala, R Gazapo, C de la Piedra |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 178
Issue 2
Pg. 320-5
(Feb 1998)
ISSN: 0002-9378 [Print] United States |
PMID | 9500493
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Collagen Type I
- Estrogen Antagonists
- Peptides
- Pyrrolidines
- Tartrates
- Thiophenes
- collagen type I trimeric cross-linked peptide
- Osteocalcin
- Ethinyl Estradiol
- LY 117018
- Collagen
- Creatinine
- Alkaline Phosphatase
- Acid Phosphatase
- Calcium
- tartaric acid
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Topics |
- Acid Phosphatase
(blood)
- Alkaline Phosphatase
(blood)
- Animals
- Body Weight
- Bone Density
(drug effects)
- Bone Remodeling
(drug effects)
- Calcium
(blood)
- Collagen
(blood)
- Collagen Type I
- Creatinine
(blood)
- Estrogen Antagonists
(pharmacology)
- Ethinyl Estradiol
(pharmacology)
- Female
- Organ Size
- Osteocalcin
(blood)
- Ovariectomy
- Peptides
(blood)
- Pyrrolidines
(pharmacology)
- Rats
- Rats, Wistar
- Tartrates
(pharmacology)
- Thiophenes
(pharmacology)
- Uterus
(anatomy & histology)
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