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Diazoxide treatment for insulinoma: a national UK survey.

Abstract
A survey of UK patients receiving the drug diazoxide, revealed 40 patients with insulinoma on this treatment. Mean age (+/- SD) was 67 +/- 18 years, and 74% were female. Duration of treatment was 7 +/- 6 years (range 1-22). Most (55%) patients were treated with diazoxide because of tumour non-localisation (including failed previous surgery). Metastatic disease (20%) and poor surgical risk (10%) were other indications. Side-effects (notably fluid retention and hirsutism) were common (47%) but not troublesome. Treatment was highly effective--59% were symptom free and 38% had only occasional symptoms. Only one patient had frequent hypoglycaemia despite treatment. We conclude that diazoxide is effective in the management of insulinoma. Side-effects are common but not problematic. Treatment should be considered for all patients not cured by surgery, or unsuitable for surgical treatment.
AuthorsG V Gill, O Rauf, I A MacFarlane
JournalPostgraduate medical journal (Postgrad Med J) Vol. 73 Issue 864 Pg. 640-1 (Oct 1997) ISSN: 0032-5473 [Print] England
PMID9497974 (Publication Type: Journal Article)
Chemical References
  • Antihypertensive Agents
  • Diazoxide
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Antihypertensive Agents (adverse effects, therapeutic use)
  • Diazoxide (adverse effects, therapeutic use)
  • Female
  • Health Care Surveys
  • Humans
  • Insulinoma (drug therapy, secondary)
  • Kidney Diseases (etiology)
  • Male
  • Middle Aged
  • Neoplasms, Unknown Primary (drug therapy)

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