Effective treatment of experimental uveitis with interleukin-1 blockers, CK 123 and CK 124.

Abstract

Interleukin-1 (IL-1) blockers are known to inhibit IL-1-induced uveitis. CK 123 and CK 124 are new IL-1 blockers which showed potent anti-uveitis actions that are more potent than the classic corticosteroid, prednisolone. In addition to anti-inflammation, CK 123 and CK 124 were also found to inhibit proliferation of fibroblast-like corneal and conjunctival cells, indicating that these compounds could be used not only as anti-uveitis agents but also as useful agents to prolong the functional period of aqueous humor outflow after trabeculectomy. It was also found that DNA and mRNA synthesis were markedly inhibited by CK 123 and CK 124, yet the protein synthesis was either untouched or enhanced.

• Authors: B Xuan, G C Chiou, Z Chen, T Yamasaki, T Okawara
• Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics (J Ocul Pharmacol Ther) Vol. 14 Issue 1 Pg. 31-44 (Feb 1998) ISSN: 1080-7683 [Print] United States
• PMID: 9493781 (Publication Type: Comparative Study, Journal Article)

Chemical References

• 4-benzylidenehydrazinocoumarin
• 5-benzylidenehydrazino-2-methylpyridazin-3(2H)-one
• Anti-Inflammatory Agents, Non-Steroidal
• Coumarins
• Hydrazines
• Interleukin-1
• Pyridazines
• Receptors, Interleukin-1

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Cell Division (drug effects)
• Cell Line
• Cornea (drug effects)
• Coumarins (therapeutic use)
• Fibroblasts (drug effects)
• Hydrazines (therapeutic use)
• Interleukin-1
• Pyridazines (therapeutic use)
• Rats
• Rats, Sprague-Dawley
• Receptors, Interleukin-1 (antagonists & inhibitors)
• Uveitis (chemically induced, drug therapy, pathology)