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[The effect of MS-551 on two VT/Vf patients in CABG: a case report].

Abstract
Uncontrollable arrhythmia is one of the causes of operative death in CABG. We report two cases of successful treatment of recurrent VT/Vf in CABG operation by MS-551. One case was a 72-year-old male, who had unstable angina and OMI with left ventricular dysfunction (LVEF 24%). After weaning from CPB, the rhythm turned into VT/Vf suddenly. Lidocaine and verapamil were not effective. VT/Vf recurred over the over. The another case was a 52-year-old male, who had OMI and effort angina. He became myocardial infarction during operation. VT/Vf occurred after the weaning from CPB. Lidocaine and amiodarone were of no effect on his VT/Vf. In both cases, intravenous injection of MS-551 promptly stopped VT/Vf. Use of MS-551 was limited mainly on DCM patients. But other antiarrhythmic agents were ineffective on these cases. We have had to continue support circulation for a long time without MS-551. As MS-551 is being used as a trial on medically followed patients, it was unknown how effective clinically on the acute myocardial infarction. In this regard, our cases may suggest a positive answer to that.
AuthorsK Uwabe, M Endo, H Nishida, Y Tomizawa, H Koyanagi, S Ohnishi, H Kasanuki
JournalKyobu geka. The Japanese journal of thoracic surgery (Kyobu Geka) Vol. 51 Issue 2 Pg. 108-11 (Feb 1998) ISSN: 0021-5252 [Print] Japan
PMID9492458 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Anti-Arrhythmia Agents
  • Pyrimidinones
  • nifekalant
Topics
  • Aged
  • Angina, Unstable (surgery)
  • Anti-Arrhythmia Agents (therapeutic use)
  • Cardiopulmonary Bypass
  • Coronary Artery Bypass
  • Humans
  • Intraoperative Care
  • Male
  • Middle Aged
  • Myocardial Infarction (surgery)
  • Pyrimidinones (therapeutic use)

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