Abstract |
In five dogs, provided with chronic pancreatic and gastric fistulas (Thomas' cannula), the effects on exocrine pancreatic secretion of an intravenous continuous perfusion of gastrin (Eurorga, hog gastrin I-II, 6 mug./kg./hr.) and secretin (GIH, 0.5 C.U./kg.hr.) was studied before and after 48 hours of reserpine treatment (0.1 mg./kg./24 hr.). When compared with the pretreated plateau levels, reserpine induced a significant pancreatic secretion dissociation, a depressive of the alkaline and a rising of the protein component. The former phenomenon suggests a participation of a catecholamines in the secretin-elicited pancreatic electrolyte secretion. The latter, an enhanced sensitivity of intranpancreatic and/or acinar cells of the "pancreon" to gastrin stimulation.
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Authors | M Voirol, O M Tiscornia, D Levesque, A Bretholz, J Dzieniszewski, G Palasciano, R Laugier, H Sarles |
Journal | The American journal of gastroenterology
(Am J Gastroenterol)
Vol. 65
Issue 5
Pg. 446-8
(May 1976)
ISSN: 0002-9270 [Print] United States |
PMID | 949051
(Publication Type: Journal Article)
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Chemical References |
- Bicarbonates
- Gastrins
- Proteins
- Secretin
- Reserpine
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Topics |
- Animals
- Bicarbonates
(metabolism)
- Dogs
- Gastrins
- Pancreas
(metabolism, physiology)
- Proteins
(metabolism)
- Reserpine
(pharmacology)
- Secretin
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