Absence of mutations in peripheral myelin protein-22, myelin protein zero, and connexin 32 in autosomal recessive Dejerine-Sottas syndrome.

Abstract

Motor and sensory neuropathies with the clinical features of HMSN III (Dejerine-Sottas syndrome, DSS) are etiologically related to heterozygous mutations in either peripheral myelin protein-22 (PMP22) or myelin protein zero (MPZ). Heterozygous mutations in either of these two genes are also responsible for other hereditary peripheral neuropathies (HNPP, CMT1A, CMT1B or CH). In two families DSS was related to the homozygous presence of a MPZ mutation while heterozygosity showed a much milder phenotype. It has therefore been suggested that the clinical phenotype in peripheral neuropathies is related to the mutated gene, the type of mutation and confounding effects from other sources. In this study we describe a family with recessive DSS in which mutations were absent from the PMP22, MPZ, and connexin 32 (Cx32) genes. We conclude that DSS also exists as a distinct genetic entity with autosomal recessive inheritance as originally defined by Dejerine and Sottas in 1893.

• Authors: F Stögbauer, P Young, H Wiebusch, V Timmerman, G Kuhlenbäumer, E Nelis, E B Ringelstein, G Kurlemann, G Assmann, C Van Broeckhoven, H Funke
• Journal: Neuroscience letters (Neurosci Lett) Vol. 240 Issue 1 Pg. 1-4 (Jan 02 1998) ISSN: 0304-3940 [Print] Ireland
• PMID: 9488160 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Twin Study)

Chemical References

• Connexins
• Myelin P0 Protein
• Myelin Proteins
• PMP22 protein, human
• connexin 32

Topics

• Child, Preschool
• Connexins (genetics)
• Electrophysiology
• Female
• Genes, Recessive
• Hereditary Sensory and Motor Neuropathy (genetics, physiopathology)
• Humans
• Male
• Mutation (genetics)
• Myelin P0 Protein (genetics)
• Myelin Proteins (genetics)
• Pedigree
• Syndrome
• Twins, Dizygotic (genetics)