Polyenzyme preparation Wobe-Mugos inhibits growth of solid tumors and development of experimental metastases in mice.

Abstract

Long-term rectal administration of enzyme mixture containing papain, trypsin and chymotrypsin in the same ratio as the preparation Wobe-Mugos E (Mucos Pharma, Germany) was evaluated for their antitumor effects in C57Bl6 inbred mice inoculated with Bl6 melanoma cells. 30% of animals in the test group (3 pcs) have been cured of cancer. In the rest of animals (70%) the survival time was prolonged by 58.3% compared to the control group (from average survival time of 24 days in control group to 38 days in the test group). Based on histological and immunohistochemical evaluation a faster process of metastasizing was found in control group than in the group treated with the polyenzyme preparation. In the case of melanoma Bl6 an antimetastatic effect of the preparation was thus proved.

• Authors: M Wald, E Závadová, P Poucková, M Zadinová, M Boubelik
• Journal: Life sciences (Life Sci) Vol. 62 Issue 3 Pg. PL43-8 ( 1998) ISSN: 0024-3205 [Print] Netherlands
• PMID: 9488106 (Publication Type: Journal Article)

Chemical References

• Drug Combinations
• Pancreatic Extracts
• Thymus Extracts
• chymotrypsin, papain, trypsin drug combination
• Chymotrypsin
• Trypsin
• Papain

Topics

• Animals
• Cell Division (drug effects)
• Chymotrypsin
• Drug Combinations
• Immunohistochemistry
• Lung Neoplasms (prevention & control, secondary)
• Melanoma, Experimental (metabolism, pathology)
• Mice
• Mice, Inbred C57BL
• Pancreatic Extracts (pharmacology)
• Papain (pharmacology)
• Thymus Extracts (pharmacology)
• Trypsin