Modulation of the antimetastatic effect of a single low dose of cyclophosphamide on rat lymphoma.

Abstract

The aim of this paper was to identify the mechanism/s responsible of the antimetastatic effect of a single low dose of cyclophosphamide (Cy), previously demonstrated by us in the rat lymphoma LTACB. No direct cytotoxic antimetastatic activity of Cy could be proved. In vitro treatment of L-TACB cells with mafosfamide did not alter their invasiveness or their motility. The adoptive transfer of splenocytes from Cy-treated tumor-bearing rats, together with L-TACB cells inhibited their metastatic growth. The single low dose Cy treatment of T-immunodeficient nude mice did not show the antimetastatic effect on L-TACB observed in immunocompetent mice. An inhibition of the metastatic ability due to immunomodulation by Cy is proposed.

• Authors: P Matar, V R Rozados, E A Roggero, R D Bonfil, O G Scharovsky
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 19 Issue 2 Pg. 69-76 ( 1998) ISSN: 1010-4283 [Print] Netherlands
• PMID: 9486558 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Alkylating
• mafosfamide
• Cyclophosphamide

Topics

• Adoptive Transfer
• Animals
• Antineoplastic Agents, Alkylating (administration & dosage, therapeutic use)
• Cell Movement (drug effects)
• Cyclophosphamide (administration & dosage, analogs & derivatives, pharmacology, therapeutic use)
• Drug Administration Schedule
• Female
• Lymphocyte Transfusion
• Lymphoma (drug therapy, pathology, therapy)
• Male
• Mice
• Mice, Nude
• Neoplasm Invasiveness
• Neoplasm Metastasis (prevention & control)
• Rats
• Rats, Inbred Strains
• Spleen (immunology)
• Splenectomy