Abstract |
The presence of activated CD4(+) T lymphocytes in psoriatic skin plaques suggests an immune-mediated pathogenesis for the disease. Six patients with recalcitrant plaque psoriasis (PASI>12) received a humanized non-depleting monoclonal antibody to CD4 ( ORTHOCLONE OKT(R)cdr4a). The antibody was well tolerated. Four weeks from treatment, the mean decrease in PASI score was 46%. In three patients disease remission was prolonged for up to 6 months and, in one case, up to 1 year post-treatment. In all patients, circulating CD4+ T-cell counts remained normal and peripheral OKTcdr4a-coated CD4+ lymphocytes were detected up to 10 days after antibody infusion. These results point to the relevance of CD4+ lymphocytes in psoriasis. They also emphasize that depletion of CD4+ cells is not mandatory to achieve therapeutic effectiveness.
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Authors | H Bachelez, B Flageul, L Dubertret, S Fraitag, R Grossman, N Brousse, D Poisson, R W Knowles, M C Wacholtz, T P Haverty, L Chatenoud, J F Bach |
Journal | Journal of autoimmunity
(J Autoimmun)
Vol. 11
Issue 1
Pg. 53-62
(Feb 1998)
ISSN: 0896-8411 [Print] England |
PMID | 9480723
(Publication Type: Journal Article)
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Copyright | Copyright 1998 Academic Press Limited. |
Chemical References |
- Antibodies, Anti-Idiotypic
- Antibodies, Monoclonal
- CD4 Antigens
- OKT4A monoclonal antibody
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Topics |
- Adult
- Animals
- Antibodies, Anti-Idiotypic
(biosynthesis)
- Antibodies, Monoclonal
(adverse effects, genetics, pharmacokinetics, therapeutic use)
- CD4 Antigens
(blood)
- CD4 Lymphocyte Count
- CD4-CD8 Ratio
- CD4-Positive T-Lymphocytes
(pathology)
- Female
- Follow-Up Studies
- Humans
- Immunohistochemistry
- Lymphocyte Depletion
- Male
- Mice
- Monitoring, Immunologic
- Psoriasis
(immunology, metabolism, pathology, therapy)
- Recurrence
- Severity of Illness Index
- Skin
(chemistry, metabolism, pathology)
- T-Lymphocytes
(metabolism)
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