[Clinical significance of betadine vaginal suppository treatment in pregnancy]

• Abstract: Clinical experience proved the efficacy of Betadine suppository in the treatment of bacterial vaginosis and mycotic infections of the vagina. Vaginal infections, frequently observed in pregnancy, can led to maternal and fetal complications, thus Betadine should be used both for prevention and therapy. One can ask if iodine absorbed from the vagina can influence the fetal thyroid function? 64 pregnant women received 7 day Betadine suppository (200 mg polyvidonum-iodine PVP) treatment for colpitis on 37-40 gestational week with excellent therapeutic result. TSH levels were measured by immunoassay in the serum of newborns 4-5 days after delivery, no signs of hypothyroidism were observed. Authors recommended 7 day Betadine vaginal suppository regimen for the prevention of intrauterine infections, treatment of mixed (bacterial, mycotical) vaginal infections, and restoration of the normal vaginal equilibrium of bacterias, since the risk of hypothyroidism is negligeable in mature newborns. In case of prematurity hypothyroidism is more frequently found also without iodine treatment therefore TSH level control is recommended in each case.
• Authors: G Gimes, F Péter (Affiliation: Semmelweis Orvostudományi Egyetem II. sz Nói Klinika.)
• Journal: Acta pharmaceutica Hungarica (Acta Pharm Hung) Vol. 67 Issue 6 Pg. 249-53 (Nov 1997) ISSN: 0001-6659 [Print] HUNGARY
• Vernacular Title: Terhesek Betadine hüvelykúp kezelésének klinikai jelentösége.
• PMID: 9480620 (Publication Type: Clinical Trial, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Anti-Infective Agents, Local
• Suppositories
• Povidone-Iodine
• Thyrotropin

Topics

• Anti-Infective Agents, Local (administration & dosage, therapeutic use)
• Bacterial Infections (drug therapy, prevention & control)
• Female
• Humans
• Infant, Newborn
• Mycoses (drug therapy, prevention & control)
• Povidone-Iodine (administration & dosage, therapeutic use)
• Pregnancy
• Pregnancy Complications, Infectious (drug therapy, prevention & control)
• Suppositories
• Thyrotropin (blood)
• Vagina
• Vaginitis (drug therapy)